ALOX5 抗体
(Arachidonate 5-Lipoxygenase (ALOX5))
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
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ALOX5 抗体 by Grade
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Cat. No.
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Quantity
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Cat. No.
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Quantity
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Datasheet
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Application
IF (cc), IF (p), IHC (p), IHC (fro)
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Quantity
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WB, IHC, ELISA, IF, ICC
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Application
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Cat. No.
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Quantity
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Reactivity
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Application
WB, IHC, ELISA
Validations
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
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Quantity
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Datasheet
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Latest Publications for our ALOX5 抗体
: "BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils." in: Scientific reports, Vol. 6, pp. 29650, (2016) (PubMed).: "The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats." in: Behavioral and brain functions : BBF, Vol. 11, pp. 18, (2015) (PubMed).
: "The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APC(Min/+) mice." in: Drug discoveries & therapeutics, Vol. 8, Issue 1, pp. 25-32, (2014) (PubMed).
: "5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts." in: PLoS ONE, Vol. 9, Issue 9, pp. e107890, (2014) (PubMed).
: "Retinal upregulation of inflammatory and proangiogenic markers in a model of neonatal diabetic rats fed on a high-fat-diet." in: BMC ophthalmology, Vol. 13, Issue 1, pp. 14, (2013) (PubMed).
: "Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 8, pp. 3132-43, (2013) (PubMed).
: "ALOX5 promoter genotype, asthma severity and LTC production by eosinophils." in: Allergy, Vol. 61, Issue 1, pp. 97-103, (2005) (PubMed).
: "Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis." in: The New England journal of medicine, Vol. 350, Issue 1, pp. 29-37, (2004) (PubMed).
: "Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523." in: The Journal of biological chemistry, Vol. 279, Issue 40, pp. 41512-20, (2004) (PubMed).
: "Elevated levels of cyclooxygenase-2 in antigen-stimulated mast cells is associated with minimal activation of p38 mitogen-activated protein kinase." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 3, pp. 1629-36, (2001) (PubMed).
Aliases for ALOX5 抗体
arachidonate 5-lipoxygenase (ALOX5) 抗体arachidonate 5-lipoxygenase (Alox5) 抗体
arachidonate 5-lipoxygenase a (alox5a) 抗体
arachidonate 5-lipoxygenase (AFUA_4G02770) 抗体
arachidonate 5-lipoxygenase (AOR_1_1362014) 抗体
Arachidonate 5-lipoxygenase (lox5) 抗体
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F730011J02 抗体
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lox5 抗体
LOX5A 抗体
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