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ALAS1 产品

(Aminolevulinate, delta-, Synthase 1 (ALAS1))
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme\; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011].

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Featured ALAS1 Categories

ALAS1 抗体

High quality antibodies with extensive validation data.

ALAS1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

ALAS1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ALAS1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (3)
Cat. No. ABIN559839
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IF (cc)
Validations
  • (2)
Cat. No. ABIN5557346
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7142600
Quantity 100 μg
Datasheet Datasheet

Recommended ALAS1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6953665
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN1742702
Quantity 96 tests
Datasheet Datasheet
Reactivity Sheep
Analytical Method
Validations
Cat. No. ABIN1773606
Quantity 96 tests
Datasheet Datasheet

Recommended ALAS1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1344797
Quantity 10 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7398293
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5505552
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our ALAS1 Products

Lazareth, Poli, Bignon, Mirmiran, Rabant, Cohen, Schmitt, Puy, Karras, Gouya, Pallet: "Renal Function Decline With Small Interfering RNA Silencing Aminolevulinic Acid Synthase 1 (ALAS1)." in: Kidney international reports, Vol. 6, Issue 7, pp. 1904-1911, (2021) (PubMed).

Ju, Mizutani, Imamichi, Yazawa, Matsumura, Kawabe, Kanno, Umezawa, Kangawa, Miyamoto: "Nuclear receptor 5A (NR5A) family regulates 5-aminolevulinic acid synthase 1 (ALAS1) gene expression in steroidogenic cells." in: Endocrinology, Vol. 153, Issue 11, pp. 5522-34, (2012) (PubMed).

Seo, Park, Jeon, Park, Park, Lee, Chang, Chun: "Gonadotropin regulation of genes differentially expressed in response to PKCzeta inhibitor during ovulation in the rat." in: Life sciences, Vol. 85, Issue 3-4, pp. 153-60, (2009) (PubMed).

Leick, Wojtaszewski, Johansen, Kiilerich, Comes, Hellsten, Hidalgo, Pilegaard: "PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle." in: American journal of physiology. Endocrinology and metabolism, Vol. 294, Issue 2, pp. E463-74, (2008) (PubMed).

Zheng, Shan, Lambrecht, Donohue, Bonkovsky: "Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin." in: Molecular and cellular biochemistry, Vol. 319, Issue 1-2, pp. 153-61, (2008) (PubMed).

Synonyms and alternative names related to ALAS1

5'-aminolevulinate synthase 1 (ALAS1), aminolevulinic acid synthase 1 (Alas1), 5'-aminolevulinate synthase 1 (Alas1), 5'-aminolevulinate synthase 1 (alas1), 5'-aminolevulinate synthase 1 (alas1.S), alanyl-tRNA synthetase protein (alaS1), aminolevulinate, delta-, synthase 1 (alas1), ALAS, Alas-1, Alas-h, ALAS-H, ALAS-N, ALAS1, ALAS3, ALASH, ALASN, MIG4, wu:fb58d01, wu:fi12g09

Protein level used designations for ALAS1

  • 5-aminolevulinate synthase, nonspecific, mitochondrial
  • 5-aminolevulinic acid synthase 1
  • ALAS-H
  • delta-ALA synthase 1
  • delta-aminolevulinate synthase 1
  • migration-inducing protein 4
  • aminolevulinate synthase H
  • succinyl-CoA: glycine C-succinyl transferase
  • 5-aminolevulinate synthase 1
  • ALA-S
  • ALAS-N
  • aminolevulinic acid synthase 1
  • delta-ALA synthetase
  • aminolevulinate, delta, synthase 1
  • delta-ALA synthetase 1
  • ALA-synthase
  • aminolevulinate, delta-, synthase 1
  • Delta-ALA synthetase
  • 5-aminolevulinate synthase, nonspecific, mitochondrial-like
  • 5-aminolevulinic acid synthase
  • alanyl-tRNA synthetase protein
  • aminolevulinate synthase 1
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