AKR1C3 产品
(Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3))
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This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
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Featured AKR1C3 Categories
AKR1C3 抗体
High quality antibodies with extensive validation data.
AKR1C3 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
AKR1C3 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended AKR1C3 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (5)
Cat. No.
ABIN6259862
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IP
Validations
- (5)
Cat. No.
ABIN3022536
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), IP, ICC
Validations
- (5)
Cat. No.
ABIN2855872
Quantity
100 μL
Datasheet
Datasheet
Recommended AKR1C3 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5594185
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4881786
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6385765
Quantity
96 tests
Datasheet
Datasheet
Recommended AKR1C3 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN666747
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1344760
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Human Cells
Validations
Cat. No.
ABIN7318144
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our AKR1C3 Products
: "Production of prostaglandins in placentae and corpus luteum in pregnant hinds of red deer (Cervus elaphus)." in: Theriogenology, Vol. 85, Issue 4, pp. 762-8, (2016) (PubMed).: "Interindividual variability in the cardiac expression of anthracycline reductases in donors with and without Down syndrome." in: Pharmaceutical research, Vol. 31, Issue 7, pp. 1644-55, (2014) (PubMed).
: "Induction of PGF2? synthesis by cortisol through GR dependent induction of CBR1 in human amnion fibroblasts." in: Endocrinology, Vol. 155, Issue 8, pp. 3017-24, (2014) (PubMed).
: "Elevated expression of AKR1C3 increases resistance of cancer cells to ionizing radiation via modulation of oxidative stress." in: PLoS ONE, Vol. 9, Issue 11, pp. e111911, (2014) (PubMed).
: "Testosterone synthesis in patients with 17β-hydroxysteroid dehydrogenase 3 deficiency." in: Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation, Vol. 6, Issue 4, pp. 161-8, (2012) (PubMed).
: "Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29." in: Chemico-biological interactions, Vol. 191, Issue 1-3, pp. 239-49, (2011) (PubMed).
: "The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate." in: Urology, Vol. 65, Issue 1, pp. 76-82, (2005) (PubMed).
Synonyms and alternative names related to AKR1C3
aldo-keto reductase family 1, member C3 L homeolog (akr1c3.L), aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (AKR1C3), aldo-keto reductase family 1 member C2 (LOC722496), aldo-keto reductase family 1 member C3 (AKR1C3), aldo-keto reductase family 1, member C3 (Akr1c3), AKR1C3, Akr1c18, DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, MGC134333, PGFSProtein level used designations for AKR1C3
- aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
- prostaglandin F synthase
- aldo-keto reductase family 1 member C3 homolog
- 3-alpha hydroxysteroid dehydrogenase, type II
- 3-alpha-HSD type II, brain
- aldo-keto reductase family 1 member C3
- chlordecone reductase homolog HAKRb
- dihydrodiol dehydrogenase 3
- dihydrodiol dehydrogenase X
- indanol dehydrogenase
- testosterone 17-beta-dehydrogenase 5
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- type IIb 3-alpha hydroxysteroid dehydrogenase
- 20 alpha-hydroxysteroid dehydrogenase
- 20-alpha-HSD
- 20-alpha-hydroxysteroid dehydrogenase
- 20alpha-hydroxysteroid dehydrogenase
- HSD1
- aldo-keto reductase family 1 member C18
- aldo-keto reductase family 1, member C18
- 17-beta-HSD 5
- 17-beta-hydroxysteroid dehydrogenase type 5
- 3-alpha-HSD type 2
- 3-alpha-hydroxysteroid dehydrogenase type 2
- PGFS
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