AKAP13 产品
(A Kinase (PRKA) Anchor Protein 13 (AKAP13))
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The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012].
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AKAP13 抗体
High quality antibodies with extensive validation data.
Recommended AKAP13 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (6)
Cat. No.
ABIN524646
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (3)
Cat. No.
ABIN564877
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, ELISA, IF, ICC
Validations
- (3)
Cat. No.
ABIN6256897
Quantity
100 μL
Datasheet
Datasheet
Recommended AKAP13 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN5648000
Quantity
96 tests
Datasheet
Datasheet
Recommended AKAP13 蛋白
Latest Publications for our AKAP13 Products
: "The mRNA and protein expression of A-kinase anchor proteins 13 in human colorectal cancer." in: Clinical and experimental medicine, Vol. 10, Issue 1, pp. 41-9, (2010) (PubMed).: "RhoA GTPase activation by TLR2 and TLR3 ligands: connecting via Src to NF-kappa B." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 6, pp. 3522-9, (2009) (PubMed).
: "The ubiquitin-like protein LC3 regulates the Rho-GEF activity of AKAP-Lbc." in: The Journal of biological chemistry, Vol. 284, Issue 41, pp. 28232-42, (2009) (PubMed).
Synonyms and alternative names related to AKAP13
A-kinase anchoring protein 13 (AKAP13), A-kinase anchoring protein 13 S homeolog (akap13.S), A kinase (PRKA) anchor protein 13 (akap13), A-kinase anchoring protein 13 (Akap13), A kinase (PRKA) anchor protein 13 (Akap13), 1700026G02Rik, 5730522G15Rik, 5830460E08Rik, AKAP-13, akap-lbc, AKAP-Lbc, AKAP13, arhgef13, ARHGEF13, brx, BRX, c-lbc, ha-3, HA-3, ht31, Ht31, lbc, LBC, MGC81410, p47, PRKA13, proto-lb, PROTO-LB, proto-lbc, PROTO-LBCProtein level used designations for AKAP13
- A kinase (PRKA) anchor protein 13
- A kinase anchor protein 13 isoform-like
- A-kinase anchor protein 13-like
- A-kinase anchor protein 13
- a-kinase anchor protein 13-like
- A-kinase anchoring protein
- LBC oncogene
- breast cancer nuclear receptor-binding auxiliary protein
- guanine nucleotide exchange factor Lbc
- human thyroid-anchoring protein 31
- lymphoid blast crisis oncogene
- non-oncogenic Rho GTPase-specific GTP exchange factor
- protein kinase A-anchoring protein 13
- protein kinase A anchoring protein Rt31
- type II cAMP-dependent protein kinase anchoring protein Ht31
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