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Kaliotoxin-1

产品编号 ABIN1540091
发货至: 中国
  • 抗原
    Kaliotoxin-1
    应用范围
    Blocking Reagent (BR)
    原理
    Kaliotoxin-1 is a BK channel inhibitor
    序列
    Gly-Val-Glu-Ile-Asn-Val-Lys-Cys8-Ser-Gly-Ser-Pro-Gln-Cys14-Leu-Lys-Pro-Cys18-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys28-Met-Asn-Arg-Lys-Cys33-His-Cys35-Thr-Pro-Lys-OHDisulfid e bonds between Cys8-Cys28, Cys14-Cys33 and Cys18-Cys35
  • 限制
    仅限研究用
  • 抗原
    Kaliotoxin-1
    背景
    Kaliotoxin-1 has been isolated from the venom of the Scorpion Androctonus mauretanicus mauretanicus. Kaliotoxin-1 is a potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). This toxin also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Kaliotoxin-1 induces atransient period of fast flickering in the channel openings, followed by an almost complete blockage of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than that of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules.
    分子量
    4150.37 Da
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