ACVR1 产品
(Activin Receptor Type I (ACRV1))
Categories
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008].
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Featured ACVR1 Categories
ACVR1 抗体
High quality antibodies with extensive validation data.
ACVR1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
ACVR1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ACVR1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, ICC, FACS
Validations
- (4)
Cat. No.
ABIN5542584
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
- (4)
Cat. No.
ABIN392240
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (5)
Cat. No.
ABIN3029855
Quantity
0.4 mL
Datasheet
Datasheet
Recommended ACVR1 ELISA试剂盒
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Reactivity
Analytical Method
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Cat. No.
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Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953435
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1742678
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Sheep
Analytical Method
Validations
Cat. No.
ABIN1773582
Quantity
96 tests
Datasheet
Datasheet
Recommended ACVR1 蛋白
Product
Reactivity
Source
Validations
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Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1305799
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1305801
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Rat
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7194131
Quantity
200 μg
Datasheet
Datasheet
Latest Publications for our ACVR1 Products
: "Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps." in: Scientific reports, Vol. 8, Issue 1, pp. 1561, (2018) (PubMed).: "Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal." in: Cell death & disease, Vol. 9, Issue 9, pp. 927, (2018) (PubMed).
: "Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2." in: Biochemical and biophysical research communications, Vol. 455, Issue 3-4, pp. 347-52, (2014) (PubMed).
: "Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification." in: Stem cells (Dayton, Ohio), Vol. 27, Issue 1, pp. 150-6, (2009) (PubMed).
: "BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury." in: American journal of physiology. Renal physiology, Vol. 293, Issue 5, pp. F1641-8, (2007) (PubMed).
: "A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva." in: Nature genetics, Vol. 38, Issue 5, pp. 525-7, (2006) (PubMed).
: "A limited set of human MicroRNA is deregulated in follicular thyroid carcinoma." in: The Journal of clinical endocrinology and metabolism, Vol. 91, Issue 9, pp. 3584-91, (2006) (PubMed).
: "EphB4 provides survival advantage to squamous cell carcinoma of the head and neck." in: International journal of cancer, Vol. 119, Issue 6, pp. 1236-48, (2006) (PubMed).
: "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia." in: Molecular human reproduction, Vol. 9, Issue 4, pp. 199-203, (2003) (PubMed).
: "The distribution of activin and activin receptors in gestational tissues across human pregnancy and during labour." in: Placenta, Vol. 23, Issue 4, pp. 294-302, (2002) (PubMed).
Synonyms and alternative names related to ACVR1
activin A receptor type 1 (ACVR1), activin A receptor type 1 (Acvr1), activin A receptor, type 1 (Acvr1), activin A receptor type 1 S homeolog (acvr1.S), ActR-I, ActR-IA, ACTRI, actri, ActRIA, Acvr, acvr1, acvr1-a, acvr1-b, ACVR1A, acvr1a, ACVRLK2, Acvrlk2, acvrlk2, Alk-2, alk-2, ALK2, alk2, Alk8, alk8, D330013D15Rik, FOP, fop, sax, SKR1, skr1, Tsk7L, TSRI, tsri, xALK-2Protein level used designations for ACVR1
- TGF-B superfamily receptor type I
- activin A receptor, type II-like kinase 2
- activin receptor type I
- activin receptor type-1
- activin receptor-like kinase 2
- hydroxyalkyl-protein kinase
- serine/threonine-protein kinase receptor R1
- ACTR-I
- SKR1
- TSR-I
- activin A receptor, type 1
- activin type I receptor
- type I TGF B receptor
- activin A receptor, type I
- activin receptor type IA
- TSK-7L
- activin A receptor type 1 S homeolog
- activin A receptor type I S homeolog
- activin receptor like kinase-2
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