Isoform 4/ATF-A0 acts as a dominant repressor of the E- selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation. Plays important functions in early cell signaling. Binds 3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.
Latest Publications for our Activating Transcription Factor 7 抗体
Hasegawa, Ishibashi, Kubota, Yamaguchi, Yuki, Nakajo, Eckner, Yamaguchi, Yokoyama, Yamaguchi: "Cdk1-mediated phosphorylation of human ATF7 at Thr-51 and Thr-53 promotes cell-cycle progression into M phase." in: PLoS ONE, Vol. 9, Issue 12, pp. e116048, (2014) (PubMed).
Hamard, Dalbies-Tran, Hauss, Davidson, Kedinger, Chatton: "A functional interaction between ATF7 and TAF12 that is modulated by TAF4." in: Oncogene, Vol. 24, Issue 21, pp. 3472-83, (2005) (PubMed).
Peters, Liang, Li, Kannan, Peng, Taub, Diamond: "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase." in: The Journal of biological chemistry, Vol. 276, Issue 17, pp. 13718-26, (2001) (PubMed).