Actin-Like 6A 抗体
(Actin-Like 6A (BAF53A))
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila\; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008].
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Popular Actin-Like 6A 抗体
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Cat. No.
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Quantity
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Cat. No.
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Quantity
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Cat. No.
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Quantity
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Quantity
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Quantity
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Chicken, Cow, Dog, Human, Mouse, Pig, Rat
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WB, IHC, IF, IC
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Cat. No.
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Quantity
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Quantity
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Quantity
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Datasheet
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Validations
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Cat. No.
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Quantity
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Cat. No.
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Quantity
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Datasheet
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Application
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Quantity
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Datasheet
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Latest Publications for our Actin-Like 6A 抗体
: "A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells." in: Nature communications, Vol. 9, Issue 1, pp. 5139, (2019) (PubMed).: "TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin." in: Nature structural & molecular biology, Vol. 24, Issue 4, pp. 344-352, (2017) (PubMed).
: "ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4." in: Cell stem cell, Vol. 12, Issue 2, pp. 193-203, (2013) (PubMed).
: "Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 25, pp. 10348-61, (2013) (PubMed).
: "Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues." in: Bioscience, biotechnology, and biochemistry, Vol. 63, Issue 5, pp. 917-23, (1999) (PubMed).
: "Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers." in: eLife, Vol. 6 (PubMed).
Aliases for Actin-Like 6A 抗体
actin like 6A (ACTL6A) 抗体actin-like 6A (Actl6a) 抗体
actin-like 6A (actl6a) 抗体
actin like 6A (actl6a) 抗体
actin-related protein 4 (ARP4) 抗体
actin like 6A (Actl6a) 抗体
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