ACSL4 产品
(Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4))
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The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].
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Featured ACSL4 Categories
Recommended ACSL4 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (1)
- (7)
Cat. No.
ABIN6136458
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), ICC, IP
Validations
- (3)
- (8)
Cat. No.
ABIN2854678
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (7)
Cat. No.
ABIN7265424
Quantity
100 μL
Datasheet
Datasheet
Recommended ACSL4 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN419350
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6212507
Quantity
96 tests
Datasheet
Datasheet
Recommended ACSL4 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1305715
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1305717
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3110368
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our ACSL4 Products
: "Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases." in: Bioscience reports, Vol. 40, Issue 4, (2020) (PubMed).: "Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death." in: Nature, Vol. 567, Issue 7746, pp. 118-122, (2019) (PubMed).
: "Morphologically and Functionally Distinct Lipid Droplet Subpopulations." in: Scientific reports, Vol. 6, pp. 29539, (2018) (PubMed).
: "A Natural Dietary Supplement with a Combination of Nutrients Prevents Neurodegeneration Induced by a High Fat Diet in Mice." in: Nutrients, Vol. 10, Issue 9, (2018) (PubMed).
: "The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells." in: Molecular and cellular biochemistry, Vol. 448, Issue 1-2, pp. 275-286, (2018) (PubMed).
: "Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid-induced insulin resistance." in: Experimental cell research, Vol. 359, Issue 1, pp. 86-93, (2017) (PubMed).
: "Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease." in: The EMBO journal, Vol. 36, Issue 22, pp. 3356-3371, (2017) (PubMed).
: "Identification of ACSL4 as a biomarker and contributor of ferroptosis." in: Biochemical and biophysical research communications, Vol. 478, Issue 3, pp. 1338-43, (2016) (PubMed).
: "Highly potent intracellular membrane-associated Aβ seeds." in: Scientific reports, Vol. 6, pp. 28125, (2016) (PubMed).
: "Isolation of Endoplasmic Reticulum, Mitochondria, and Mitochondria-Associated Membrane and Detergent Resistant Membrane Fractions from Transfected Cells and from Human Cytomegalovirus-Infected ..." in: Current protocols in cell biology, Vol. 68, pp. 3.27.1-33, (2016) (PubMed).
Synonyms and alternative names related to ACSL4
acyl-CoA synthetase long chain family member 4a (acsl4a), acyl-CoA synthetase long-chain family member 4 (ACSL4), acyl-CoA synthetase long chain family member 4 (ACSL4), AcsL4 (acsL4), acyl-CoA synthetase long chain family member 3 (acsl3), Long-chain-fatty-acid--CoA ligase 4 (acsl4), acyl-CoA synthetase long-chain family member 4 (Acsl4), acyl-CoA synthetase long-chain family member 4 S homeolog (acsl4.S), AMP-dependent synthetase and ligase family protein (LACS4), 9430020A05Rik, ACS4, Acs4, acs4, acsl3, acsl4, ACSL4, AU018108, FACL4, Facl4, facl4, LACS4, Lacs4, lacs4, long-chain acyl-CoA synthetase 4, MRX63, mrx63, MRX68, mrx68, T32A16.20, T32A16_20, zgc:66186Protein level used designations for ACSL4
- acyl-CoA synthetase long-chain family member 4
- long-chain-fatty-acid--CoA ligase 4
- AcsL4
- Long-chain-fatty-acid--CoA ligase 4
- long-chain-fatty-acid--CoA ligase 4-like
- LACS 4
- acyl-CoA synthetase 4
- fatty-acid-Coenzyme A ligase, long-chain 4
- lignoceroyl-CoA synthase
- long-chain acyl-CoA synthetase 4
- long-chain fatty-acid-Coenzyme A ligase 4
- fatty acid-Coenzyme A ligase, long chain 4
- mACS4
- fatty acid Coenzyme A ligase, long chain 4
- fatty acid-Coenzyme A ligase long chain 4
- acyl-CoA synthetase long-chain family member 3
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