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ABCC8 产品

(ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8))
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed\; however, the transcript variants have not been fully described. [provided by RefSeq, Jul 2008].

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Featured ABCC8 Categories

ABCC8 抗体

High quality antibodies with extensive validation data.

ABCC8 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

ABCC8 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ABCC8 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, ICC, IHC (p), IHC (fro)
Validations
  • (3)
Cat. No. ABIN7441085
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, ICC, IF
Validations
  • (3)
Cat. No. ABIN1027723
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, ICC, IF
Validations
  • (3)
Cat. No. ABIN2482997
Quantity 100 μg
Datasheet Datasheet

Recommended ABCC8 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6953985
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5652076
Quantity 96 tests
Datasheet Datasheet

Recommended ABCC8 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1305467
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7407961
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2714263
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our ABCC8 Products

Gerzanich, Stokum, Ivanova, Woo, Tsymbalyuk, Sharma, Akkentli, Imran, Aarabi, Sahuquillo, Simard: "Sulfonylurea Receptor 1, Transient Receptor Potential Cation Channel Subfamily M Member 4, and KIR6.2:Role in Hemorrhagic Progression of Contusion." in: Journal of neurotrauma, Vol. 36, Issue 7, pp. 1060-1079, (2019) (PubMed).

Luu, Bjork, Salo, Entenmann, Jurgenson, Fisher, Klein: "Modulation of SUR1 KATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice." in: International journal of molecular sciences, Vol. 20, Issue 9, (2019) (PubMed).

Vázquez-Sánchez, Hinojosa, Parraguirre-Martínez, González, Morales, Montalvo, Vera, Hernández-Gallegos, Camacho: "Expression of KATP channels in human cervical cancer: Potential tools for diagnosis and therapy." in: Oncology letters, Vol. 15, Issue 5, pp. 6302-6308, (2018) (PubMed).

Němcová-Fürstová, Kopperová, Balušíková, Ehrlichová, Brynychová, Václavíková, Daniel, Souček, Kovář: "Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters." in: Toxicology and applied pharmacology, Vol. 310, pp. 215-228, (2016) (PubMed).

Harel, Cohen, Hussain, Flanagan, Schlade-Bartusiak, Patel, Courtade, Li, Van Karnebeek, Kurata, Ellard, Chanoine, Gibson: "Alternating hypoglycemia and hyperglycemia in a toddler with a homozygous p.R1419H ABCC8 mutation: an unusual clinical picture." in: Journal of pediatric endocrinology & metabolism : JPEM, Vol. 28, Issue 3-4, pp. 345-51, (2015) (PubMed).

Bruin, Erener, Vela, Hu, Johnson, Kurata, Lynn, Piret, Asadi, Rezania, Kieffer: "Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells." in: Stem cell research, Vol. 12, Issue 1, pp. 194-208, (2014) (PubMed).

Karnik, Ludlow, Abuarab, Smith, Hardy, Elliott, Sivaprasadarao: "Endocytosis of HERG is clathrin-independent and involves arf6." in: PLoS ONE, Vol. 8, Issue 12, pp. e85630, (2014) (PubMed).

Li, Huang, Zhang, Kim, Yang, Kurata: "Decomposition of slide helix contributions to ATP-dependent inhibition of Kir6.2 channels." in: The Journal of biological chemistry, Vol. 288, Issue 32, pp. 23038-49, (2013) (PubMed).

Park, Ryu, Yu, Han, Ji, Oh, Sohn, Lim, Jeon, Lee, Lee, Lee, Berggren, Jeon, Ho: "Leptin promotes K(ATP) channel trafficking by AMPK signaling in pancreatic ?-cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 31, pp. 12673-8, (2013) (PubMed).

de Wet, Rees, Shimomura, Aittoniemi, Patch, Flanagan, Ellard, Hattersley, Sansom, Ashcroft: "Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 48, pp. 18988-92, (2007) (PubMed).

Synonyms and alternative names related to ABCC8

ATP binding cassette subfamily C member 8 (ABCC8), ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (Abcc8), ATP binding cassette subfamily C member 8 (Abcc8), ABC36, D930031B21Rik, HHF1, HI, HRINS, MRP8, PHHI, SUR, Sur, SUR1, Sur1, SUR1delta2, TNDM2

Protein level used designations for ABCC8

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • ATP-binding cassette, sub-family C, member 8
  • ATP-binding cassette sub-family C member 8
  • ATP-binding cassette transporter sub-family C member 8
  • sulfonylurea receptor (hyperinsulinemia)
  • sulfonylurea receptor 1
  • sulfonylurea receptor
  • sulphonylurea receptor 1
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