ABCB1 产品
(ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 (ABCB1))
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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008].
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Featured ABCB1 Categories
ABCB1 抗体
High quality antibodies with extensive validation data.
ABCB1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
ABCB1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ABCB1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC (p), IHC (fro)
Validations
- (30)
- (5)
Cat. No.
ABIN3043967
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IHC (p)
Validations
- (7)
Cat. No.
ABIN1491725
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, IHC (p)
Validations
- (5)
Cat. No.
ABIN1491724
Quantity
100 μL
Datasheet
Datasheet
Recommended ABCB1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (2)
Cat. No.
ABIN6965064
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965066
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965065
Quantity
96 tests
Datasheet
Datasheet
Recommended ABCB1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1305435
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121929
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505266
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ABCB1 Products
: "Microphysiological Conditions Do Not Affect MDR1-Mediated Transport of Rhodamine 123 above an Artificial Proximal Tubule." in: Biomedicines, Vol. 11, Issue 7, (2023) (PubMed).: "Association Analysis of Single-Cell RNA Sequencing and Proteomics Reveals a Vital Role of Ca2+ Signaling in the Determination of Skeletal Muscle Development Potential." in: Cells, Vol. 9, Issue 4, (2021) (PubMed).
: "Hypoxia-tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-Associated Hypoxia." in: ACS nano, Vol. 13, Issue 1, pp. 236-247, (2019) (PubMed).
: "PAMAM dendrimer grafted cellulose paper scaffolds as a novel in vitro 3D liver model for drug screening applications." in: Colloids and surfaces. B, Biointerfaces, Vol. 172, pp. 346-354, (2019) (PubMed).
: "Manganese transporter Slc30a10 controls physiological manganese excretion and toxicity." in: The Journal of clinical investigation, Vol. 129, Issue 12, pp. 5442-5461, (2019) (PubMed).
: "MicroRNA-139-5p affects cisplatin sensitivity in human nasopharyngeal carcinoma cells by regulating the epithelial-to-mesenchymal transition." in: Gene, Vol. 652, pp. 48-58, (2018) (PubMed).
: "Increased autophagy in EOC re-ascites cells can inhibit cell death and promote drug resistance." in: Cell death & disease, Vol. 9, Issue 4, pp. 419, (2018) (PubMed).
: "Brusatol Enhances the Chemotherapy Efficacy of Gemcitabine in Pancreatic Cancer via the Nrf2 Signalling Pathway." in: Oxidative medicine and cellular longevity, Vol. 2018, pp. 2360427, (2018) (PubMed).
: "Role of P-glycoprotein inhibitors in children with drug-resistant epilepsy." in: Acta neurologica Scandinavica, Vol. 136, Issue 6, pp. 639-644, (2018) (PubMed).
: "Positive Feedback Loop of OCT4 and c-JUN Expedites Cancer Stemness in Liver Cancer." in: Stem cells (Dayton, Ohio), Vol. 34, Issue 11, pp. 2613-2624, (2018) (PubMed).
Synonyms and alternative names related to ABCB1
ATP binding cassette subfamily B member 1 (ABCB1), ATP binding cassette subfamily B member 1A (Abcb1a), ATP binding cassette subfamily B member 1 L homeolog (abcb1.L), ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b), ATP binding cassette subfamily B member 1 (Abcb1), ABC20, Abcb1, ABCB1, CD243, CLCS, GP170, mdr, MDR1, Mdr1, Mdr1a, Mdr1b, P-GP, p-gp, PGP1, Pgy-1, PGY1, Pgy1, xemdrProtein level used designations for ABCB1
- P-glycoprotein 1
- colchicin sensitivity
- doxorubicin resistance
- multidrug resistance protein 1
- ATP-binding cassette, sub-family B (MDR/TAP), member 1
- ATP-binding cassette, subfamily B (MDR/TAP), member 1A
- multiple drug resistant 1a
- bovine P-glycoprotein
- ATP-binding cassette, subfamily B, member 1
- P-glycoprotein
- multidrug resistance p-glycoprotein
- multidrug resistance protein
- ATP-binding cassette sub-family B member 1
- P glycoprotein 1
- multidrug resistance protein 1B
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