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AANAT 产品

(Aralkylamine N-Acetyltransferase (AANAT))
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].

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Featured AANAT Categories

AANAT 抗体

High quality antibodies with extensive validation data.

AANAT ELISA试剂盒

Reliable ELISA kits for a wide range of species.

AANAT 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended AANAT 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat, Sheep
Application ELISA, WB, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
  • (2)
  • (6)
Cat. No. ABIN751063
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, ICC, IP
Validations
  • (2)
Cat. No. ABIN7444538
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IF
Validations
  • (2)
Cat. No. ABIN7169324
Quantity 100 μg
Datasheet Datasheet

Recommended AANAT ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965002
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965001
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6953911
Quantity 96 tests
Datasheet Datasheet

Recommended AANAT 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1305403
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7395332
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7418458
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our AANAT Products

Xiao, Hu, Song, Zhang, Dong, Jiang, Zhang, Yuan, Zhao: "Profile of melatonin and its receptors and synthesizing enzymes in cumulus-oocyte complexes of the developing sheep antral follicle-a potential estradiol-mediated mechanism." in: Reproductive biology and endocrinology : RB&E, Vol. 17, Issue 1, pp. 1, (2019) (PubMed).

Ahn, Park, Kim, Lee, Yan, Yong, Lee, CHoi, Yoo, Hwang, Moon, Shin, Won: "Comparison of arylalkylamine N-acetyltransferase and melatonin receptor type 1B immunoreactivity between young adult and aged canine spinal cord." in: Journal of veterinary science, Vol. 15, Issue 3, pp. 335-42, (2016) (PubMed).

Klein: "Arylalkylamine N-acetyltransferase: "the Timezyme"." in: The Journal of biological chemistry, Vol. 282, Issue 7, pp. 4233-7, (2007) (PubMed).

Klein, Ganguly, Coon, Shi, Gaildrat, Morin, Weller, Obsil, Hickman, Dyda: "14-3-3 proteins in pineal photoneuroendocrine transduction: how many roles?" in: Journal of neuroendocrinology, Vol. 15, Issue 4, pp. 370-7, (2003) (PubMed).

Iuvone, Brown, Haque, Weller, Zawilska, Chaurasia, Ma, Klein: "Retinal melatonin production: role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase." in: Investigative ophthalmology & visual science, Vol. 43, Issue 2, pp. 564-72, (2002) (PubMed).

Klein, Ganguly, Coon, Weller, Obsil, Hickman, Dyda: "14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin." in: Biochemical Society transactions, Vol. 30, Issue 4, pp. 365-73, (2002) (PubMed).

Coon, Del Olmo, Young, Klein: "Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87)." in: The Journal of clinical endocrinology and metabolism, Vol. 87, Issue 10, pp. 4699-706, (2002) (PubMed).

Coon, Weller, Korf, Namboodiri, Rollag, Klein: "cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 24097-107, (2001) (PubMed).

Synonyms and alternative names related to AANAT

aralkylamine N-acetyltransferase (AANAT), aralkylamine N-acetyltransferase (Aanat), arylalkylamine N-acetyltransferase (Aanat), AA-NAT, DSPS, Nat-2, Nat4, SNAT, Snat

Protein level used designations for AANAT

  • arylalkylamine N-acetyltransferase
  • serotonin N-acetyltransferase
  • serotonin acetylase
  • Arylalkylamine N - acetyltransferase (Serotonin N - acetyltransferase)
  • Seretonin N-acetyltransferase
  • arylakylamine N-acetyltransferase
  • AA-NAT
  • pineal serotonin N-acetyltransferase
  • pineal arylalkylamine N-acetyltransferase
  • aralkylamine N-acetyltransferase
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